陳曦    教授、碩/博導(dǎo)

  Professor Xi CHEN

  Email：chenxi@ecust.edu.cn

  所屬組室：教育部醫(yī)用生物材料工程研究中心

  辦公地點(diǎn)：徐匯校區(qū)新材料大樓1007

教育背景 Education

    學(xué)士(2009）材料科學(xué)與工程，吉林大學(xué)

    碩士(2012）材料科學(xué)與工程，清華大學(xué)

    博士(2016）化學(xué)與生物分子工程，墨爾本大學(xué)

工作經(jīng)歷 Work Experience

    博士后（2016-2017）美國加州大學(xué)洛杉磯分校

    博士后（2017-2019）美國哈佛大學(xué)

    副教授（2019-2025）華東理工大學(xué)/材料科學(xué)與工程學(xué)院

    教   授（2025 - 至今）華東理工大學(xué)/材料科學(xué)與工程學(xué)院

主要學(xué)術(shù)/社會(huì)兼職 Part-time Job

          中國生物材料學(xué)會(huì)神經(jīng)修復(fù)材料分會(huì)、再生醫(yī)學(xué)材料分會(huì)/委員

          國際華人骨研學(xué)會(huì)/終身會(huì)員

          上海市科普志愿者協(xié)會(huì)《院士專家科學(xué)詮釋者指導(dǎo)團(tuán)》/青年科普專家

主要教學(xué)課程 Teaching

    本科生《生物材料》（上海市重點(diǎn)課程）

    研究生《生物醫(yī)學(xué)工程前沿進(jìn)展》（校思政示范課程）、《納米材料毒理學(xué)與安全性》

    卓越工程師《生物材料與再生醫(yī)學(xué)工程》（校一流研究生課程）

研究方向 Research Interests

    功能化細(xì)胞外基質(zhì)材料構(gòu)建及其促神經(jīng)再生機(jī)制研究

    骨靶向納米材料構(gòu)建及其生物學(xué)效應(yīng)研究

    材料生物學(xué)研究新技術(shù)與新方法，如：器官芯片與類器官、超高分辨顯微鏡等

主要科研項(xiàng)目 Research Funding

    國家自然科學(xué)基金委員會(huì), 面上項(xiàng)目，2024.01-2027.12，主持

    國家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目，2022.11-2025.10，子課題負(fù)責(zé)人

    中央高校基本科研業(yè)務(wù)費(fèi)項(xiàng)目，2022.01-2022.12，主持

    國家自然科學(xué)基金委員會(huì)，青年項(xiàng)目，2022.01-2024.12，主持

    中央高校基本科研業(yè)務(wù)費(fèi)項(xiàng)目，2021.01-2021.12，主持

學(xué)生培養(yǎng) & 招生專業(yè) Student Recruitment

自2020年以來，指導(dǎo)博士生6名，研究生10余名；其中1名研究生獲得國家獎(jiǎng)學(xué)金、上海市優(yōu)秀畢業(yè)生；1名獲華東理工大學(xué)優(yōu)秀畢業(yè)生；7名研究生獲校一等獎(jiǎng)學(xué)金；3人次獲中國生物材料大會(huì)優(yōu)秀海報(bào)獎(jiǎng)

招收專業(yè)：材料科學(xué)與工程（學(xué)碩）、生物醫(yī)學(xué)工程（學(xué)碩）、材料工程/材料與化工（專碩）。課題組每年招收1名博士生，3-6名碩士生，歡迎對生物材料感興趣的同學(xué)，將個(gè)人簡歷發(fā)至郵箱，包括所獲獎(jiǎng)勵(lì)、報(bào)考分?jǐn)?shù)、成績單等。To prospective students, please contact chenxi@ecust.edu.cn for more information

入職華理后發(fā)表的學(xué)術(shù)論文 Publications@Ecust

20. Sixian Zhang, Yiwei Zeng, Sixu Zhang, Jiajing Zhou*, Changsheng Liu*, Xi Chen*.Metal-phenolic network coated coacervate system mediates mitochondrial modulation and bone homeostasis restoration for postmenopaupal osteoporosis therapy. Nano Letters  2025

19. Shu Chen, Bixue Wang, Qiya Zhang, Changsheng Liu*, Xi Chen*. Neuroprotection and axonal regeneration via ECM-mimetic nanofibers incorporating metal–phenolic network nanoparticles toward spinal cord injury repair. Advanced Science 2025

18. Sixu Zhang, Sixian Zhang, Wenwen Fan, Changsheng Liu, Xi Chen*. Promoting ROS scavenging and osteogenic differentiation by metal–phenolic network nanoparticle-embedded microenvironment-responsive hydrogel for the repair of senile osteoporotic bone defects. Journal of Materials Chemistry B 2025, 13, 10043

17. Yuexin Wang, Shu Chen, Sixian Zhang, Wenwen Fan, Xi Chen*. Cell ratio-dependent osteoblast–endothelial cell crosstalk ing osteogenesis–angiogenesis coupling via regulation of microfluidic perfusion and paracrine signaling. Micromachine 2025, 16, 539

16. Bixue Wang, Qiya Zhang, Changsheng Liu*, Xi Chen*. Counteracting immunodepression by extracellular matrix hydrogel to e brain tissue remodeling and neurological function recovery after traumatic brain injury. Biomaterials 2025, 318, 123181

15. Xi Chen, Yuan Yuan, Yeqiang Tan*, Changsheng Liu*. Strategic study on the development of inorganic non-metallic biomaterials. 無機(jī)材料學(xué)報(bào) 2025, 40, 449

14. Xi Chen*, Weihui Wu, Wei Zhu, Jiajing Zhou, Jingqu Chen, Zhixing Lin, Sixian Zhang, Frank Caruso*, Changsheng Liu*. Regulation of bone remodeling by metal–phenolic networks for the treatment of systemic osteoporosis. ACS Applied Materials & Interfaces 2025, 17, 4, 5995

13.  Ruijia Yan, Shu Chen, Bixue Wang, Changsheng Liu, Xi Chen*. Magnetic field-oriented conductive decellularized extracellular matrix hydrogel synergizes with electrical stimulation to e spinal cord injury repair and electrophysiological function restoration. Biomaterials Advances 2025, 169, 214169

12. Zhiqiang Tai, Jiashang Liu, Bixue Wang, Shu Chen, Changsheng Liu, Xi Chen*. The effect of aligned and random electrospun fibers derived from porcine decellularized ECM on mesenchymal stem cell-based treatments for spinal cord injury. Bioengineering 2024, 11, 772 

11. Jiashang Liu, Ruijia Yan, Bixue Wang, Shu Chen, Hua Hong, Changsheng Liu, Xi Chen* Decellularized extracellular matrix enriched with GDNF enhances neurogenesis and remyelination for improved motor recovery after spinal cord injury. Acta Biomaterialia  2024, 180, 308

10. Ying Wang, Fangru Xie, Zirui He, Lingbin Che, Xi Chen*, Yuan Yuan*, Changsheng Liu*. Senescence targeted and NAD dependent SIRT1 activated nanoplatform to counteract stem cell senescence for ing aged bone regeneration. Small 2024, 20, 2304433

9. Zirui He, Chuanhao Sun, Yifan Ma, Xi Chen, Ying Wang, Kai Chen, Fangru Xie, Yan Zhang, Yuan Yuan*, Changsheng Liu*. Rejuvenating aged bone repair through multihierarchy reactive oxygen species-regulated hydrogel. Advanced Materials 2024, 36, 9

8．Ying Wang, Lingbin Che, Xi Chen, Zirui He, Dianwen Song*, Yuan Yuan*, Changsheng Liu*. Repurpose dasatinib and quercetin: Targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration. Bioactive Materials 2023,25,13

7．Shuaimin Tang, Dongyong Sha, Zirui He, Xi Chen, Yifan Ma*, Changsheng Liu*, Yuan Yuan*. Environmentally adaptable organo–ionic gel-based electrodes for real-time on-skin electrocardiography monitoring. Advanced Healthcare Materials 2023,12, 2300475

6．Xuewei Zhang, Bixue Wang, Hua Hong, Ying Wang, Jiashang Liu, Changsheng Liu*, Xi Chen*. Decellularized extracellular matrix and mesenchymal stem cells e recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating neuroinflammation. Journal of Materials Science & Technology 2023, 138, 17

5．Xiaolong Zhan#, Zhengbo Wen#, Xi Chen*, Qi Lei, Yuxin Chen, Liang Zhou, Guansheng Zheng, Fanhui Kong, Jimin Guo, Yuyou Duan, Yuyan Lai, Panchao Yin, C. Jeffrey Brinker, Honglin Chen*; Wei Zhu*. Polyphenol-mediated biomimetic mineralization of sacrificial metal-organic framework nanoparticles for wound healing. Cell Reports Physical Science 2022, 3, 101103

4．Xi Chen, Shuyan Han, Weihui Wu, Zihan Wu, Yuan Yuan*, Jun Wu*, Changsheng Liu. Harnessing 4D printing bioscaffolds for advanced orthopedics. Small 2022, 18, 2106824

3．Xuewei Zhang, Xi Chen*, Hua Hong, Rubei Hu, Jiashang Liu, ChangshengLiu*. Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering. Bioactive Materials 2022, 10,15 

2．Xi Chen*, Yu Wang, Xuewei Zhang，and Changsheng Liu*. Advances in super-resolution fluorescence microscopy for the study of nano–cell interactions. Biomaterials Science 2021, 9, 5484

1．Xi Chen*, Yu Shrike Zhang, Xinping Zhang, Changsheng Liu*. Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine. Bioactive Materials 2021, 6,1012