姓名

性別

職稱

所屬教研室

李玉林

男

教授

教育部醫(yī)用生物材料工程研究中心

E-mail

yulinli@ecust.edu.cn

辦公室

實驗十五樓-724室

主要研究方向：

長期致力于可吸收醫(yī)用高分子與醫(yī)療器械的應(yīng)用研究。以第一/通訊作者在Chem. Rev., Adv. Funct. Mater., Biomaterials,ACS Nano等學(xué)術(shù)刊物發(fā)表文章100余篇，申請（授權(quán)）發(fā)明專利10余項（1項PCT專利）。擔(dān)任International Journal of Molecular Sciences和Gels等國際SCI學(xué)術(shù)期刊的客座編輯。承擔(dān)國家重點研發(fā)計劃課題1項、國家重點研發(fā)計劃子課題2項、軍委科技委項目、國家自然科學(xué)基金面上項目2項、及省部級項目十余項，獲上海市人才發(fā)展基金和甌越海智英才計劃資助。所開發(fā)的可吸收骨釘獲得“第二十三屆中國國際高新技術(shù)成果交易會優(yōu)秀產(chǎn)品獎”，并入選為“先導(dǎo)技術(shù)”榜單（生物醫(yī)藥領(lǐng)域）。

人才培養(yǎng)與國際交流：

擔(dān)任高材161和材料2002班班導(dǎo)師，指導(dǎo)2項USRP和4項大學(xué)生創(chuàng)新項目。分別指導(dǎo)大學(xué)生獲得第一屆上海市大學(xué)生生命科學(xué)競賽三等獎、第十三屆“華陸科技·奮進杯”大學(xué)生課外學(xué)術(shù)科技作品競賽二等獎等。自2014年以來指導(dǎo)研究生28名，其中6名碩士研究生（許欣、羅煒、鄭玲、張世豪、林安琪、蔡佩昊）獲得國家獎學(xué)金、1名博士研究生（王宜峰）獲校優(yōu)秀學(xué)生稱號、4名碩士研究生（鄭玲、張世豪、林安琪、蔡佩昊）獲得校優(yōu)秀畢業(yè)生稱號，7名碩士研究生（王雅琪、鄭玲、羅煒、陳璨、許夢瑤、林安琪、蔡佩昊）獲校一等獎學(xué)金。分別指導(dǎo)研究生獲得第三屆國際納米藥物大會JACS最佳墻報獎（鄭玲）、中國生物材料大會產(chǎn)業(yè)化論壇創(chuàng)新創(chuàng)業(yè)大賽三等獎、第二屆青年學(xué)術(shù)論文優(yōu)秀獎評選一等獎（羅煒）、2021生物材料大會優(yōu)秀墻報獎（蔡佩昊）、2023生物材料大會優(yōu)秀墻報獎（趙政）。積極參與包括“111”引智計劃在內(nèi)的國際學(xué)術(shù)交流活動，注重具有國際視野的材料領(lǐng)域年輕人才培養(yǎng)，指導(dǎo)2名學(xué)生（劉天舒、陳占立）獲得國家獎學(xué)金赴澳留學(xué)。

主要經(jīng)歷與簡歷：

近期代表性論文:

1.       生物可吸收高分子基納米活性材料及植入器械制備技術(shù)（課題負責(zé)人 / 274.0萬元 / 2019-2024）/國家重點研發(fā)計劃

2.       高品質(zhì)聚乳酸纖維及其紡織品規(guī)模化制備與應(yīng)用（子課題負責(zé)人/ 80.0萬元 / 2017-2021）/國家重點研發(fā)計劃

3.       新型高強度可吸收復(fù)合生物活性骨固定器械研發(fā)（子課題負責(zé)人/ 100.0萬元 / 2022-2027）/國家重點研發(fā)計劃

4.       JG（**急救**技術(shù)研究）（主持 / 130.0萬元 / 2022-2023）/軍委科技委項目

5.       非細胞型活性仿生支架促進老年骨損傷修復(fù)應(yīng)用研究（主持 / 62.0萬元 / 2020-2023）/國家自然科學(xué)基面上項目

6.       兼具干細胞募集能力和成骨誘導(dǎo)功能的微納結(jié)構(gòu)活性材料的構(gòu)建及快速成骨機制研究（主持 / 66.0萬元 / 2020-2023）/國家自然科學(xué)基面上項目

7.       納米控釋材料開發(fā)（主持 / 300.0萬元 / 2021-2022）/華東理工大學(xué)—鄭州賽科藥業(yè)科技有限公司技術(shù)開發(fā)項目

8.       兼具成血管能力的水凝膠聯(lián)合基因工程化內(nèi)源性脂肪干細胞治療脊髓損傷研究（主持 / 40.0萬元 / 2018-2021）/上海市科委港澳臺科技合作項目

9.       基于微納結(jié)構(gòu)的高彈高強復(fù)合活性骨修復(fù)材料的研究（主持 / 10.0萬元 / 2015-2017）/上海市國際科技合作基金

10.     強度可控的多級微納結(jié)構(gòu)活性支架材料與生長因子協(xié)同骨修復(fù)研究（主持 / 30.0萬元 / 2015-2017）/上海市國際科技合作基金

11.     基于3D打印技術(shù)構(gòu)建高強度活性支架材料與生長因子協(xié)同骨修復(fù)研究（主持 / 10.0萬元 / 2015-2017）/上海市人才發(fā)展基金

12.     仿生骨多級結(jié)構(gòu)活性支架材料的構(gòu)建及促進骨組織快速修復(fù)的研究（主持 / 16.0萬元 / 2017-2018）/教育部基本科研業(yè)務(wù)費

13.     Self-assembled Nanoparticles based on PEG-PLA-dendrimer building blocks for dual gene/drug delivery（主持 / 15.7萬歐 / 2012-2015）/葡萄牙科技部納米專項

近期代表性論文

1.      Shengyang Liu, Shicheng He, Can Chen, Chunwang Li, Wei Luo, Jing Wang, Hongyan He, Qiang Chen*, Yulin Li*. A versatile disorder-to-order technology to upgrade polymers into high-performance bioinspired materials. Adv. Healthc. Mater. 2023, 12, 2300068. (IF=10.0)

2.      Xiaohuan Yuan, Wei Yang, Yingying Fu, Ziwei Tao, Lan Xiao, Qinzhou Zheng, Dan Wu, Mengya Zhang, Luxin Li, Zhengmao Lu, Yan Wu*, Jie Gao*, Yulin Li*. Four-arm polymer-guided formation of curcumin-loaded flower-like porous microspheres as injectable cell carriers for diabetic wound healing. Adv. Healthc. Mater. 2023, 12, 2301486. (IF=10.0)

3.      Yamin Li, Lan Xiao, Daixu Wei, Shengyang Liu, Yin Xiao, Changsheng Liu*, Yulin Li*, Jinzhong Zhao*. Injectable biomimetic hydrogel guided functional bone regeneration by adapting material degradation to tissue healing. Adv. Funct. Mater. 2023, 34, 2213047. (IF=19.0)

4.      Yulin Li, Yin Xiao, Changsheng Liu*. The horizon of materiobiology: A perspective on material-guided cell behaviors and tissue engineering. Chem. Rev. 2017, 117, 4376. (IF=62.1)

5.        An Chen, Hongwei Lu, Rong Cao, Yi Zhu, Yumeng Li, Renbin Ge, Siruo Zhang, Yulin Li, Lan Xiao, Li Su, Jinhua Zhao*, Honggang Hu*, Zhongling Wang*. A novel MMP-responsive nanoplatform with transformable magnetic resonance property for quantitative tumor bioimaging and synergetic chemo-photothermal therapy[J]. Nano Today, 2022, 45, 101524.(IF=18.7)

6.        Qichen Zhang, Wang Ding, Shenglong Ding, Qingbing Meng, Dihan Su, Taiwei Zhang, Qing Chen, Ruixian Lian, Mingdong Zhao, Baqing Yu, Xilei Li*, Yulin Li*, Li-Bo Jiang*. Robust bioactive protein-based screws with dual crosslinked network for internal bone fixation[J]. Composites Part B-Engineering, 2022, 238,109884. (IF=11.2)

7.        Zhichao Hu, Jiaqi Lu, Annan Hu, Yongjiang Dou, Sheng Wang, Dihan Su, Wang Ding, Ruixian Lian, Shunyi Lu, Lan Xiao, Yu-Lin Li, Jian Dong, Jian Zhou, Xuyong Yang*, Libo Jiang*. Engineering BPQDs/PLGA nanospheres-integrated wood hydrogel bionic scaffold for combinatory bone repair and osteolytic tumor therapy[J]. Chemical Engineering Journal, 2022, 4, 137269. (IF=16.4)

8.        Yamin Li, Can Chen, Jia Jiang, Shengyang Liu, Zeren Zhang, Lan Xiao, Ruixian Lian, Lili Sun, Wei Luo, Michael Tim-yun Ong, Wayne Yuk-wai Lee, Yunsu Chen, Jinzhong Zhao*, Changsheng Liu*, Yulin Li*. Bioactive Film-guided Soft–Hard Interface Design Technology for Multi-tissue Integrative Regeneration, Advanced Science, 2022, 9(15), 2105945. (IF=16.9)

9.        Fei Yu, Ruixian Lian, Lu Liu, Ting Liu, Chao Bi, Kan Hong, Shuiquan Zhang, Jiazi Ren, Haikun Wang, Ningjuan Ouyang, Lin-Juan Du, Yuan Liu, Lujun Zhou, Yan Liu, Bing Fang*, Yulin Li*, Sheng-Zhong Duan*, and Lunguo Xia* Biomimetic Hydroxyapatite Nanorods Promote Bone Regeneration via Accelerating Osteogenesis of BMSCs through T Cell-Derived IL-22[J]. ACS Nano, 2022, 16(1), 755-770. (IF=17.7)

10.     Fangxue Zhang, Peng Liu, Wang Ding, Qingbing Meng, Dihan Su, Qichen Zhang, Ruixian Lian, Baoqing Yu, Mingdong Zhao, Jian Dong, Yulin Li*, Li-Bo Jiang. Injectable Mussel‐Inspired highly adhesive hydrogel with exosomes for endogenous cell recruitment and cartilage defect regeneration. Biomaterials, 2021, 278, 121169 (IF=15.2)

11.     Wei Hu, Tingting Xiao, Du Li, Yu Fan, Lingxi Xing*, Xipeng Wang, Yulin Li*, Xiangyang Shi*, Mingwu Shen*. Intelligent Molybdenum Disulfide Complexes as a Platform for Cooperative Imaging-Guided Tri-mode Chemo-Photothermo-Immunotherapy. Advanced Science, 2021,8(14),2100165.(IF=16.9)

12.     Kaikai Zheng, Yu Tong, Shihao Zhang, Ruiying He, Lan Xiao, Zoya Iqbal, Yuhong Zhang, Jie Gao*, Lei Zhang, Libo Jiang*, Yulin Li*. Flexible Bicolorimetric Polyacrylamide/Chitosan Hydrogels for Smart Real‐Time Monitoring and Promotion of Wound Healing. Advanced Functional Materials. 2021, 31(34), 2102599. (IF: IF=19.0)

13.     Shihao Zhang, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu*, Yulin Li*. Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration. Bioactive Materials, 2021, 6, 3461-3472. (IF=16.8)

14.     Libo Jiang, Shenglong Ding, Wang Ding, Dihan Su, Fangxue Zhang, Taiwei Zhang, Xiaofan Yin, Lan Xiao, Yulin Li*, Fenglai Yuan, Jian Dong. Injectable Sericin Based Nanocomposite Hydrogel for Multi-modal Imaging-guided Immunomodulatory Bone Regeneration. Chemical Engineering Journal, 2021, 418, 129323.(IF=16.4)

15.     Yulin Li, Yin Xiao, Changsheng Liu*. The Horizon of Materiobiology: A Perspective on Material-Guided Cell Behaviors and Tissue Engineering. Chemical Reviews, 2017, 117(5), 4376?4421. (IF=62.1)

16.     Panpan Yi, Yifeng Wang, Shihao Zhang, Yuan Zhan, Yuhong Zhang, Zhengguang Sun, Yulin Li,* and Peixin He. Stimulative Nanogels with Enhanced Thermosensitivity for Therapeutic Delivery via β-Cyclodextrin-induced Formation of Inclusion Complexes. Carbohydrate Polymers, 2017, 166, 219-227. (IF=10.6)

17.     Guoying Wang, Yaying Chen, Peng Wang, Yifeng Wang, Hua Hong, Yulin Li, Jiangchao Qian, Yuan Yuan, Bo Yu, Changsheng Liu*. Preferential Tumor Accumulation and Desirable Interstitial Penetration of Poly(lactic-co-glycolic acid) Nanoparticles with Dual Coating of Chitosan Oligosaccharide and Polyethylene glycol-poly(D,L-lactic acid). Acta Biomaterialia, 2016, 29, 248–260. (IF=10.5)

18.     Yulin Li*, Dina Maciel, Jo?o Rodrigues, Xiangyang Shi, Helena Tomás. Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery. Chemical Reviews, 2015, 115(16), 8564-8608. (IF=62.1)

19.     Mara Gon?alves, Priscilla Figueira, Dina Maciel, Jo?o Rodrigues, Xue Qu, Changsheng Liu, Helena Tomás, Yulin Li*. pH-sensitive Laponite? /doxorubicin/alginate Nanohybrids with Improved Anticancer Efficacy, Acta Biomaterialia, 2014, 10(1), 300-307. (IF: 10.5)

20.     Yulin Li*, Jo?o Rodrigues and Helena Tomás. Injectable and Biodegradable Hydrogels: Gelation, Biodegradation and Biomedical Applications, Chemical Society Reviews, 2012, 41(6), 2193-2221. (IF: 46.2)