周敏  副研究員、博導(dǎo)

       研究組室：生物大分子研究室    

      招生專業(yè)：材料科學(xué)與工程、材料工程（博士/學(xué)碩/專碩）

      辦公地點(diǎn)：徐匯校區(qū)科輔二樓二層C203

      E-mail：minzhou@ecust.edu.cn；minzhou072@163.com

個(gè)人簡介：

     華東理工大學(xué)材料科學(xué)與工程學(xué)院，副研究員。2021年博士畢業(yè)于華東理工大學(xué)材料科學(xué)與工程專業(yè)，獲工學(xué)博士學(xué)位。2021年至2024年在華東理工大學(xué)開展博士后研究，后留校任教。先后入選華東理工大學(xué)青年英才培育計(jì)劃B類項(xiàng)目（2025）、國家青年科學(xué)基金B(yǎng)類項(xiàng)目（2026）。

 聚焦于生物醫(yī)藥、生物材料領(lǐng)域抗耐藥菌感染研究，通過模擬天然多肽，設(shè)計(jì)發(fā)現(xiàn)抗耐藥菌非天然骨架聚多肽。以第一/通訊作者在Nature Biotechnology、Nature Microbiology、Science Translational Medicine、Nature Communications（2篇）、Angewandte Chemie International Edition（3篇）、Advanced Functional Materials 等期刊發(fā)表研究論文26篇，論文成果多次被國家自然科學(xué)基金委收錄為基金資助重要成果。申請PCT專利1件、中國專利5件（3件授權(quán)）。入選國家“博新計(jì)劃”和上海市“超級(jí)博士后”，獲國家自然科學(xué)基金青年項(xiàng)目和博士后科學(xué)基金面上一等項(xiàng)目等資助。

課題組研究方向：http://www.f6zm.cn/2019/1209/c4944a102096/page.htm（課題組PI鏈接）

主持科研項(xiàng)目：

1. 國家青年科學(xué)基金B(yǎng)類項(xiàng)目，2026.01-2028.12

2. 國家自然科學(xué)基金青年項(xiàng)目，2024.01-2026.12

3. 國家“博士后創(chuàng)新人才”支持計(jì)劃，2021.07-2023.06

4. 上海市“超級(jí)博士后”激勵(lì)計(jì)劃，2021.07-2023.06

5. 中國博士后科學(xué)基金面上資助一等項(xiàng)目，2022.09-2024.08

代表性研究論文：

1. Zhou, M.^#; Liu, L.^#; Cong, Z.; Jiang, W.; Xiao, X.; Xie, J.; Luo, Z.;Chen, S.; Wu, Y.; Shao, N.; Liu, R.* A Dual-Targeting Antifungal is Effective against Multidrug-resistant Human Fungal Pathogens. Nat. Microbiol. 2024, 9, 1325. (#equal contribution, ESI Highly cited paper, Highlighted by BioCentury Innovations, 入選國家自然科學(xué)基金委2024年度報(bào)告)

2. Xie, J.^#; Zhou, M.^#; Cong, Z.; Xiao, X.; Liu, L.; Chen, S.; Jiang, W.; Wu, Y.;Liu, R.* A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections. Sci. Transl. Med. 2025, 17, eadl4870. (Cover, Highlighted by Nature Reviews Drug Discovery 2025, 24, 586; Highlighted by Cell Host & Microbe, 2025, 33, 1315)

3. Liu, L.^#; Zhou, M.^#; Xiao, X.; Cong, Z.; Wu, Y.; Xie, J.; Zhang, Q.; Zhang, J.; Jiang, W.; Liu, R.*Combinatorial synergistic antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles. Nat. Biotechnol. 2025, DOI: 10.1038/s41587-025-02874-8.

4. Zhou, M.; Qian, Y.; Xie, J.; Zhang, W.; Jiang, W.; Xiao, X.; Chen, S.; Dai, C.; Cong, Z.; Ji, Z.; Shao, N.; Liu, L.; Wu, Y.; Liu, R.* Poly(2-Oxazoline)-Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance. Angew. Chem. Int. Ed. 2020, 59, 6412. (Inside Cover, Selected as Very Important Paper, ESI Highly cited paper, Highlighted by American Peptide Society)

5. Zhou, M.; Xiao, X.; Cong, Z.; Wu, Y.; Zhang, W.; Ma, P.; Chen, S.; Zhang, H.; Zhang, D.; Zhang, D.; Luan, X.; Mai, Y.; Liu, R.* Water Insensitive Synthesis of Poly-β-Peptides with Defined Architecture. Angew. Chem. Int. Ed. 2020, 59, 7240.  (Highlighted by NSFC)

6. Xie, J.^#; Zhou, M.^#; Qian, Y.; Cong, Z.; Chen, S.; Zhang,W.; Jiang, W.; Dai, C.; Shao, N.; Ji, Z.; Zou, J.; Xiao, X.; Liu, L.; Chen, M.; Li, J.;Liu, R.* Addressing MRSA Infection and Antibacterial Resistance with Peptoid Polymers. Nat. Commun. 2021, 12, 5898. (Highlighted by BioCentury Innovations, ESI Highly cited paper)

7. Wu, T.^#; Zhou, M.^#; Zou, J.; Chen, Q.; Qian, F.; Kurths, J.; Liu, R.*; Tang, Y.* Few-shot Inverse Design of HDP-Mimicking Polymers against Drug-Resistant Bacteria. Nat. Commun. 2024, 15, 6288. (Highlighted by NSFC)

8. Jiang, W.^#; Zhou, M.^#; Cong, Z.; Xie, Jia.; Zhang,W.; Chen, S.; Zou, J.; Ji, Z.; Shao, N.; Chen,X.; Li, M.; Liu, R.* Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections. Angew. Chem. Int. Ed. 2022, 134, e202200778. (Selected as Very Important Paper) 

9. Xie, J.; Liu, Z.; Zhou, M.*;Luo, Z.; Liu, L.;Xiao, X.; Jiang, W.; Hu, W.; Wu, Y.; Liu, R.* Self-assembled poly(sarcosine) functionalized host defense peptide-mimicking poly-β-peptides for combating drug-resistant fungal infection. Adv. Funct. Mater. 2025, 35, 2424125. 

10. Luo, Z.; Zhao, X.; Zhou, M.*; Zou, J.; Xiao, X.; Liu, L.; Xie, J.; Wu, Y.; Zhang, W.; Liu, R.* Peptide-mimicking Poly(2-oxazoline)s as Adjuvants to Enhance Activities and Antibacterial Spectrum of Polymyxin B. Sci. China. Mater. 2024, 67, 991.

11. Cong, Z.; Yan, Z.; Xiao, X.; Liu, L.; Luo, Z.; Zou, J.; Chen, M.; Wu, Y.; Zhou, M.*; Liu, R.* Peptide-Mimicking Poly(2-oxazoline) Displaying Potent Antibacterial and Antibiofilm Activities Against Multidrug-resistant Gram-Positive Pathogenic Bacteria. J. Mater. Sci. Technol. 2025, 214, 233.