俞遠(yuǎn)滿  副教授  碩士生導(dǎo)師

            Email: ymyu@ecust.edu.cn     

              所屬教研室：生物材料

         工作地點(diǎn)：先進(jìn)材料大樓1005

教育與工作經(jīng)歷

2024.01-至今                     華東理工大學(xué)           材料科學(xué)與工程學(xué)院           副教授

2021.01-2023.12                華東理工大學(xué)              材料科學(xué)與工程                博士后

2016.09-2020.09                華東理工大學(xué)              材料科學(xué)與工程                  博士

2012.09-2015.06                華東理工大學(xué)              材料科學(xué)與工程                  碩士

2008.09-2012.06                 浙江工業(yè)大學(xué)              材料科學(xué)與工程                  學(xué)士

主要研究方向

仿生促血管化生物材料的構(gòu)建

材料生物學(xué)效應(yīng)在缺血性疾病中的治療與應(yīng)用

免疫微環(huán)境與原位再生

主要成果

主要工作從事促血管化生物材料的構(gòu)建及其在心梗、腦卒中等重大缺血性疾病中的應(yīng)用，闡明生物材料與宿主微環(huán)境多細(xì)胞相互調(diào)控規(guī)律與機(jī)制。共發(fā)表SCI論文38篇，其中以第一作者及通訊作者發(fā)表于PNAS、Science Advances、Nature Communications、Biomaterials等期刊11篇，并撰寫2部英文專著章節(jié)。論文總他引千余次。主持國家自然科學(xué)基金面上項(xiàng)目、國家自然科學(xué)基金青年基金、中國博士后基金面上項(xiàng)目，參與基金委基礎(chǔ)科學(xué)中心及國家自然科學(xué)基金重點(diǎn)項(xiàng)目。成功入選博士后創(chuàng)新人才支持計(jì)劃及上海市“超級博士后” 激勵(lì)計(jì)劃。

代表性論文

1. Yuanman Yu^# *, Rui Chen^#, Xinye Chen, Jing Wang*, Changsheng Liu*. Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration. Bioactive Materials, 2024, 38, 169-180.

2. Yinli Cao, Yuanman Yu*, Lina Pan, Weili Han, Feng Zeng, Jing Wang*, Qiyong Mei*, Changsheng Liu. Sulfated Polysaccharide-Based Nanocarrier Drives Microenvironment-Mediated Cerebral Neurovascular Remodeling for Ischemic Stroke Treatment. Nano Letters, 2024, 24(17), 5214-5223.

3. Yuanman Yu, Shuang Wang, Xinye Chen, Zehua Gao, Kai Dai, Jing Wang*, Changsheng Liu*. Sulfated oligosaccharide activates endothelial Notch for inducing macrophage-associated arteriogenesis to treat ischemic diseases. PNAS, 2023, 120:e2307480120. (Direct submission).

4. Shengqiang Chen^#, Yuanman Yu^#, Songqing Xie^#, Dandan Liang, Wei Shi, Sizhen Chen, Guanglin Li, Wei Tang*, Changsheng Liu*, Qianjun He*. Local H₂ release remodels senscence microenvironment for improved repair of injured bone. Nature Communications, 2023, 14:7783.

5. Xinye Chen, Shuang Wang, Xiaohui Zhang, Yuanman Yu*, Jing Wang*, Changsheng Liu*. Dual-function injectable fibrin gel incorporated with sulfated chitosan nanoparticles for rhBMP-2-induced bone regeneration. Applied Materials Today, 26 (2022) 101347.

6. Yuanman Yu, Kai Dai, Zehua Gao, Wei Tang, Tong Shen, Yuan Yuan, Jing Wang*, Changsheng Liu*. Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages, Science Advances, 2021, 7(7): eabd8217.

7. Wei Tang^#, Yuanman Yu^#, Jing Wang, Hui Liu, Haobo Pan, Guocheng Wang*, Changsheng Liu*. Enhancement and orchestration of osteogenesis and angiogenesis by a dualmodular design of growth factors delivery scaffolds and 26SCS decoration, Biomaterials, 2020, 232: 119645.

8. Yuanman Yu, Rui Chen, Yuan Yuan, Jing Wang*, Changsheng Liu*. Affinity-selected polysaccharide for rhBMP-2-induced osteogenesis via BMP receptor activation, Applied Materials Today, 2020, 20: 100681.

9. Yuanman Yu, Rui Chen, Yi Sun, Yuanzhong Pan, Wei Tang, Shuang Zhang, Lingyan Cao, Yuan Yuan, Jing Wang*, Changsheng Liu*. Manipulation of VEGF-induced angiogenesis by 2-N, 6-O-sulfated chitosan, Acta Biomaterialia, 2018, 71: 510-521.

10. Yuanman Yu, Jie Chen, Rui Chen, Lingyan Cao, Wei Tang, Dan Lin, Jing Wang*, Changsheng Liu*. Enhancement of VEGF-Mediated Angiogenesis by 2-N,6-O-Sulfated Chitosan-Coated Hierarchical PLGA Scaffolds, ACS Applied Materials & Interfaces, 2015, 7(18): 9982-9990.

代表性著作

1. Fangping Chen, Xiaoyu Ma, Yuanman Yu, Changsheng Liu. Calcium Phosphate Bone Cements: Their Development and Clinical Applications. Developments and Applications of Calcium Phosphate Bone Cements. Springer. 2017.

2. Fangping Chen, Yuanman Yu, Xiaoyu Ma, Changsheng Liu. Injectable Calcium Phosphate Cements for Hard Tissue Repair. Developments and Applications of Calcium Phosphate Bone Cements. Springer. 2017.

專利

1. 劉昌勝; 戴凱; 王靖; 俞遠(yuǎn)滿; 鄧順書; 朱富威. 一種類骨膜組織的仿生構(gòu)建方法. CN114246985A.

2. 劉昌勝; 錢江潮; 何亞清; 謝倩; 俞遠(yuǎn)滿; 甘琪; 岳述榮; 魏東升. 一種快速測定骨形態(tài)發(fā)生蛋白2活性的方法. CN114252410A.